Before the Bench
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Our research program focuses on better understanding of the molecular mechanisms of cancer development and translating that knowledge to novel treatment modalities for childhood cancers. Our primary goal is to develop small molecules that will become the next generation of medicines for Ewing Sarcoma, Osteosarcoma and Rhabdomyosarcoma.
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Ewing Sarcoma
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We study multiple signaling pathways that regulate growth of Ewing sarcoma cells in vitro and in vivo. We look for opportunities to repurpose existing drugs for new uses in Ewing sarcoma treatment through targeting specific protein functions.
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Osteosarcoma
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We investigate the mechanism of metastasis and develop small molecule inhibitors that can reduce the metastatic potential of osteosarcoma cells. Our work primarily focuses on a cytoplasmic protein called ezrin and its role in osteosarcoma metastasis.
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Rhabdomyosarcoma
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We aim to develop small molecule inhibitors for the tumor specific fusion protein Pax3-Foxo1.
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